Before we get into how agmatine works, we need to understand the basics of NO and the nitric oxide synthase (NOS) enzymes. NO is a signaling molecule and is involved in the regulation of the cardiovascular, nervous and immune systems. The regulation and function of NO is dependent on the dynamic regulation of its enzyme, NOS. There are three types of NOS, endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS). eNOS generates NO in the endothelial cells of blood vessels (cardiovascular system), nNOS generates NO in the nervous system and iNOS generates NO in the immune system.
Agmatine upregulates eNOS in the endothelial cells that line the walls of blood vessels. By increasing the activity of eNOS, agmatine can boost NO production in blood vessels and this means an increase in blood flow and greater muscle pumps and nutrient delivery!
NO in the nervous system is generated by nNOS and in the immune system by iNOS. Agmatine inhibits both nNOS and iNOS enzymes and this can have beneficial effects because too much NO production in the nervous and immune systems can actually compromise them. Agmatine is really an NO modulator and isn’t just a simple NO booster like arginine. It affects each of the three NOS enzymes in a different way. Agmatine upregulates eNOS so you can get better pumps and blood flow and inhibits nNOS and iNOS, which provides neuroprotective, anti-inflammatory and immune-boosting benefits.
As a dietary supplement, adults take 1 serving (506 mg) 1-2 times daily.
KEEP OUT OF REACH OF CHILDREN. Do not use if pregnant or nursing. Not intended for use by persons under the age of 18. Consult a health care professional prior to use if you have any known or suspected medical conditions, and/or if you are taking any OTC or presciption medications. Store in a cool, dry place.